Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
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منابع مشابه
Pharmacokinetics of Oral Taurine in Healthy Volunteers
Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet. Little is known of the pharmacokinetics of taurine in man after oral administration. We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22-45) following orally administration in the fasting state in the morning. Blood samples were taken at regular intervals an...
متن کاملPharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers
BACKGROUND The pharmacology of single doses of acetylsalicylic acid (ASA) administered intravenously (250 or 500 mg) or orally (100, 300, or 500 mg) was evaluated in a randomized, placebo-controlled, crossover study. METHODS Blood and urine samples were collected before and up to 24 hours after administration of ASA in 22 healthy volunteers. Pharmacokinetic parameters and measurements of plat...
متن کاملPharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers.
Pharmacokinetic studies of GdDTPA/dimeglumine in man show a rapid renal clearance and no evidence for dissociation or retention of the complex in the body. These features, in conjunction with its strong proton relaxation enhancement and its low toxicity suggest that this complex may be an excellent contrast medium for magnetic resonance imaging.
متن کاملSingle dose pharmacokinetics of oral artemether in healthy Malaysian volunteers.
AIMS To determine the pharmacokinetics of artemether (ARM) and its principal active metabolite, dihydroartemisinin (DHA) in healthy volunteers. METHODS Six healthy male Malaysian subjects were given a single oral dose of 200 mg artemether. Blood samples were collected to 72 h. Plasma concentrations of the two compounds were measured simultaneously by reversed-phase h.p.l.c. with electro-chemi...
متن کاملPosaconazole Pharmacokinetics in Healthy Cats after Oral and Intravenous Administration
BACKGROUND Posaconazole is the most active available azole antifungal drug, but absorption and pharmacokinetics are not available to guide dosing regimens in cats. OBJECTIVE To determine the pharmacokinetics of posaconazole in cats given an IV solution and PO suspension. ANIMALS Six healthy, adult research cats. METHODS After a 12-hour fast, each cat received 15 mg/kg of posaconazole PO s...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2016
ISSN: 2050-6511
DOI: 10.1186/s40360-016-0052-2